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| Interactions: | Cotrimoxazole
Adverse Effect: antagonism of Cotrimoxazole antibacterial effect Clinical Management: Avoid use of Benzocaine or para amino benzoic acid (PABA) derivatives in patients receiving Cotrimoxazole, consider alternative therapy.
Hyaluronidase
Adverse Effect: an increased incidence of a systemic reaction to the anesthetic Clinical Management: Monitor patients for local anesthetic toxicity. Hyaluronidase effectively increases topical diffusion of local anesthetics. However, due to its propensity to increase the incidence of systemic reactions to local anesthetics and because there are newer anesthetic agents which penetrate very effectively, its use can no longer be justified.
Sulfamoxole
Adverse Effect: antagonism of the sulfonamides antibacterial effect Clinical Management: Avoid use of Benzocaine or para-aminobenzoic acid (PABA)derivatives in patients receiving Sulfamoxole consider alternative therapy.
Sulphadiazine
Adverse Effect: antagonism of the sulfonamides antibacterial effect Clinical Management: Avoid use of Benzocaine or para-aminobenzoic acid (PABA) derivatives in patients receiving Sulphadiazine, consider alternative therapy. |
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